The present application discloses a multilingual translation configuration method and device for a DCS upper computer application. The method can realize the language translation of a real-time and non-interference synchronous update application during production through operations such as the generation of translation files on-line, the setting of configuration information of a language translation file, and the synchronous issuing of multi-node to ensure real-time and security during the update of a multilingual translation file of an application to a maximum extent, prompt usability of the application software of the upper computer and user experience, and greatly improve simplicity and real-time during a configuration of the language translation file on the premise of ensuring security.